Set ninety-seven years after a nuclear war has destroyed civilization, when a spaceship housing humanity's lone survivors sends one hundred juvenile delinquents back to Earth, in hopes of possibly re-populating the planet.

The missions of the Strategic Homeland Intervention, Enforcement and Logistics Division.

Raymond "Red" Reddington, one of the FBI's most wanted fugitives, surrenders in person at FBI Headquarters in Washington, D.C. He claims that he and the FBI have the same interests: bringing down dangerous criminals and terrorists. In the last two decades, he's made a list of criminals and terrorists that matter the most but the FBI cannot find because it does not know they exist. Reddington calls this "The Blacklist". Reddington will co-operate, but insists that he will speak only to Elizabeth Keen, a rookie FBI profiler.